Audiological monitoring in Swiss childhood cancer patients

PanCareLIFE researchers at UNIBE have just published a new paper ‘Audiological monitoring in Swiss childhood cancer patients’, funded in part by PanCareLIFE.

Pediatric Blood & Cancer, 65(3) e26877, DOI: 10.1080/08880018.2017.1323985

Abstract

Background

Full audiological monitoring is the best strategy to detect hearing loss early and to provide timely intervention in the absence of a clinical method of otoprotection. Full monitoring requires audiological evaluation before, and then during and after ototoxic cancer treatment. In a worldwide context of monitoring protocols that vary substantially, we analyzed the audiological monitoring of childhood cancer patients over the last decade across treatment centers in Switzerland.

Procedure

We retrospectively searched for audiological evaluations in all nine Swiss Pediatric Oncology Centers. We analyzed proportions of patients who had audiological monitoring and described type and timing of monitoring. We determined predictors of audiological monitoring using multivariable logistic regression and described time trends.

Results

We included 185 patients from the Swiss Childhood Cancer Registry diagnosed from 2005 to 2013 who had platinum chemotherapy and/or cranial radiation ≥30 Gray and who were alive at time of study. Less than half of children, 43%, had full audiological monitoring (before, during, and after treatment), while 72% were tested after cancer treatment. Nonstudy patients were less likely to have had monitoring in all phases of cancer treatment. Patients who received treatment with cisplatin or both platinum chemotherapy and cranial radiation were more likely to have had monitoring after treatment. Monitoring during and after treatment increased over the study period, but monitoring before treatment was insufficient in all time periods.

Conclusions

Our population-based study indicates that audiological monitoring is insufficient in Switzerland, particularly for nonstudy patients. Clinicians must become more aware of the importance of full audiological monitoring.

Hearing loss after platinum treatment is irreversible in non-cranial irradiated childhood cancer survivors

PanCareLIFE researchers at EMC, VUmc, AMC, PMC and UKM have just published a new paper ‘Hearing loss after platinum treatment is irreversible in noncranial irradiated childhood cancer survivors’, funded in part by PanCareLIFE.

Pediatric Hematology and Oncology, 34:2, 120-129, DOI: 10.1080/08880018.2017.1323985

You can read the full, open access article here.

Validation of questionnaire-reported hearing with medical records: A report from the Swiss Childhood Cancer Survivor Study

PanCareLIFE researchers at the University of Bern have just published a new paper ‘Validation of questionnaire-reported hearing with medical records: A report from the Swiss Childhood Cancer Survivor Study’, funded in part by PanCareLIFE. You can read the full, open access article here.

Determinants of ototoxicity in 451 platinum-treated Dutch survivors of childhood cancer: A DCOG late-effects study

PanCareLIFE researchers at EMC, VUmc, AMC, PMC and UKM have published ‘Determinants of ototoxicity in 451 platinum-treated Dutch survivors of childhood cancer: A DCOG late-effects study’, funded in part by PanCareLIFE.

European Journal of Cancer (2016) 69: 77, DOI: 10.1016/j.ejca.2016.09.023

PanCareLIFE Publication on Fertility Preservation Guidelines

Our publication ‘Fertility preservation in children, adolescents, and young adults with cancer: Quality of clinical practice guidelines and variations in recommendations’ has been published in Cancer (2016 Jul 15;122(14):2216-23. doi: 10.1002/cncr.30047.).

You can read the full, open access article here.

CANCER June 2016

 

PanCareLIFE in Pediatrie pro praxi

In December 2015, PanCareLIFE researcher Dr. Jarmila Kruseová from FN Motol in Prague published an article ‘Follow-up of oncologically cured children by general practitioners’ in Pediatrie pro praxi, a Czech medical journal.

Pediatr praxi

PanCareLIFE in Vox Pediatriae

In September 2015, PanCareLIFE researcher Dr. Jarmila Kruseová from FN Motol in Prague has published an article ‘Late Effects after Treatment of Solid Tumours in Children in Vox Pediatriae, a Czech magazine for pediatricians.

Vox pediatr

PanCareLIFE and PanCareSurFup partners publish ‘Childhood cancer survivor cohorts in Europe’

A new publication from PanCareLIFE and PanCareSurFup partners about ‘Childhood cancer survivor cohorts in Europe’ has been published in Acta Oncologica.

The paper presents an overview of the current large, national and pan-European studies of late effects after childhood cancer, in particular the EU-funded collaborative research projects PanCareSurFup and PanCareLIFE. The large cohort studies described in the paper aim to provide every European childhood cancer survivor with better care and better long-term health so that they reach their full potential and enjoy the same quality of life and opportunities as their peers, as much as is possible.

Read More: http://informahealthcare.com/doi/abs/10.3109/0284186X.2015.1008648